USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P10644 USC-OGP 2-DE database:  P10644 P10644 General information about the entry View entry in simple text format Entry name KAP0_HUMAN Primary accession number P10644 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=cAMP-dependent protein kinase type I-alpha regulatory subunit; AltName: Full=Tissue-specific extinguisher 1; Short=TSE1; Contains: RecName: Full=cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;. Gene name Name=PRKAR1A Synonyms=PKR1, PRKAR1, TSE1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0685: pI=5.13; Mw=47741 Cross-references UniProtKB/Swiss-Prot P10644; KAP0_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name KAP0_HUMAN Primary accession number P10644 Secondary accession number(s) K7ER48 Q567S7 Sequence was last modified on  July 1, 1989 (version 1) Annotations were last modified on  March 15, 2017 (version 200) Name and origin of the protein Description RecName: Full=cAMP-dependent protein kinase type I-alpha regulatory subunit; AltName: Full=Tissue-specific extinguisher 1; Short=TSE1; Contains: RecName: Full=cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Gene name Name=PRKAR1A Synonyms=PKR1, PRKAR1, TSE1 Encoded on Name=PRKAR1A; Synonyms=PKR1, PRKAR1, TSE1 Keywords Acetylation; Alternative splicing; cAMP; cAMP-binding; Cell membrane; Complete proteome; Cushing syndrome; Direct protein sequencing; Disease mutation; Disulfide bond; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M18468; AAB50922.1; -; mRNA EMBL M33336; AAB50921.1; -; mRNA EMBL S54705; -; NOT_ANNOTATED_CDS; mRNA EMBL S54707; -; NOT_ANNOTATED_CDS; mRNA EMBL S54709; -; NOT_ANNOTATED_CDS; mRNA EMBL S54711; -; NOT_ANNOTATED_CDS; mRNA EMBL Y07642; CAA68925.1; -; mRNA EMBL AC079210; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC036285; AAH36285.1; -; mRNA EMBL BC093042; AAH93042.1; -; mRNA CCDS CCDS11678.1; -. [P10644-1]; . CCDS CCDS62307.1; -. [P10644-2]; . PIR A34627; OKHU1R; . RefSeq NP_001263218.1; NM_001276289.1. [P10644-1]; . RefSeq NP_001263219.1; NM_001276290.1. [P10644-2]; . RefSeq NP_001265362.1; NM_001278433.1. [P10644-1]; . RefSeq NP_002725.1; NM_002734.4. [P10644-1]; . RefSeq NP_997636.1; NM_212471.2. [P10644-1]; . RefSeq NP_997637.1; NM_212472.2. [P10644-1]; . RefSeq XP_011523285.1; XM_011524983.2. [P10644-1]; . RefSeq XP_011523286.1; XM_011524984.2. [P10644-1]; . RefSeq XP_011523287.1; XM_011524985.2. [P10644-1]; . UniGene Hs.280342; -; . UniGene Hs.745160; -; . ProteinModelPortal P10644; -; . BioGrid 111559; 87; . DIP DIP-34368N; -; . IntAct P10644; 80; . MINT MINT-1194164; -; . STRING 9606.ENSP00000351410; -; . DrugBank DB02527; Cyclic Adenosine Monophosphate; . DrugBank DB02315; Cyclic Guanosine Monophosphate; . DrugBank DB05798; GEM-231; . GuidetoPHARMACOLOGY 1472; -; . iPTMnet P10644; -; . PhosphoSitePlus P10644; -; . SwissPalm P10644; -; . DMDM 125193; -; . OGP P10644; -; . REPRODUCTION-2DPAGE IPI00021831; -; . EPD P10644; -; . MaxQB P10644; -; . PaxDb P10644; -; . PeptideAtlas P10644; -; . PRIDE P10644; -; . DNASU 5573; -; . Ensembl ENST00000358598; ENSP00000351410; ENSG00000108946. [P10644-1]; . Ensembl ENST00000392711; ENSP00000376475; ENSG00000108946. [P10644-1]; . Ensembl ENST00000536854; ENSP00000445625; ENSG00000108946. [P10644-1]; . Ensembl ENST00000586397; ENSP00000466459; ENSG00000108946. [P10644-1]; . Ensembl ENST00000588188; ENSP00000468106; ENSG00000108946. [P10644-2]; . Ensembl ENST00000589228; ENSP00000464977; ENSG00000108946. [P10644-1]; . GeneID 5573; -; . KEGG hsa:5573; -; . UCSC uc002jhg.5; human. [P10644-1]; . CTD 5573; -; . DisGeNET 5573; -; . GeneCards PRKAR1A; -; . GeneReviews PRKAR1A; -; . HGNC HGNC:9388; PRKAR1A; . HPA CAB019378; -; . HPA HPA049979; -; . MalaCards PRKAR1A; -; . MIM 101800; phenotype; . MIM 160980; phenotype; . MIM 188830; gene; . MIM 255960; phenotype; . MIM 610489; phenotype; . neXtProt NX_P10644; -; . OpenTargets ENSG00000108946; -; . Orphanet 950; Acrodysostosis; . Orphanet 280651; Acrodysostosis with multiple hormone resistance; . Orphanet 520; Acute promyelocytic leukemia; . Orphanet 1359; Carney complex; . Orphanet 615; Familial atrial myxoma; . Orphanet 189439; Primary pigmented nodular adrenocortical disease; . PharmGKB PA33754; -; . eggNOG KOG1113; Eukaryota; . eggNOG COG0664; LUCA; . GeneTree ENSGT00530000062947; -; . HOGENOM HOG000196669; -; . HOVERGEN HBG002025; -; . InParanoid P10644; -; . KO K04739; -; . OMA FDAMFPC; -; . OrthoDB EOG091G0F1K; -; . PhylomeDB P10644; -; . TreeFam TF314920; -; . Reactome R-HSA-163615; PKA activation; . Reactome R-HSA-164378; PKA activation in glucagon signalling; . Reactome R-HSA-180024; DARPP-32 events; . Reactome R-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; . Reactome R-HSA-432040; Vasopressin regulates renal water homeostasis via Aquaporins; . Reactome R-HSA-5610787; Hedgehog 'off' state; . Reactome R-HSA-983231; Factors involved in megakaryocyte development and platelet production; . SignaLink P10644; -; . SIGNOR P10644; -; . ChiTaRS PRKAR1A; human; . GenomeRNAi 5573; -; . PRO PR:P10644; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000108946; -; . CleanEx HS_PRKAR1A; -; . ExpressionAtlas P10644; baseline and differential; . Genevisible P10644; HS; . GO GO:0005952; C:cAMP-dependent protein kinase complex; IEA:Ensembl; . GO GO:0097546; C:ciliary base; TAS:Reactome; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0031594; C:neuromuscular junction; IEA:Ensembl; . GO GO:0031588; C:nucleotide-activated protein kinase complex; IDA:BHF-UCL; . GO GO:0044853; C:plasma membrane raft; IDA:UniProtKB; . GO GO:0043234; C:protein complex; IDA:LIFEdb; . GO GO:0030552; F:cAMP binding; IEA:UniProtKB-KW; . GO GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IDA:BHF-UCL; . GO GO:0008603; F:cAMP-dependent protein kinase regulator activity; IDA:BHF-UCL; . GO GO:0034236; F:protein kinase A catalytic subunit binding; IPI:UniProtKB; . GO GO:0031625; F:ubiquitin protein ligase binding; IDA:UniProtKB; . GO GO:0034199; P:activation of protein kinase A activity; TAS:Reactome; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl; . GO GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome; . GO GO:0007143; P:female meiotic division; IEA:Ensembl; . GO GO:0035556; P:intracellular signal transduction; TAS:ProtInc; . GO GO:0001707; P:mesoderm formation; IEA:Ensembl; . GO GO:0046007; P:negative regulation of activated T cell proliferation; IMP:UniProtKB; . GO GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IDA:BHF-UCL; . GO GO:0045835; P:negative regulation of meiotic nuclear division; IEA:Ensembl; . GO GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc; . GO GO:0003091; P:renal water homeostasis; TAS:Reactome; . GO GO:0045214; P:sarcomere organization; IEA:Ensembl; . Gene3D 2.60.120.10; -; 2; . InterPro IPR012198; cAMP_dep_PK_reg_su; . InterPro IPR003117; cAMP_dep_PK_reg_su_I/II_a/b; . InterPro IPR018490; cNMP-bd-like; . InterPro IPR018488; cNMP-bd_CS; . InterPro IPR000595; cNMP-bd_dom; . InterPro IPR014710; RmlC-like_jellyroll; . Pfam PF00027; cNMP_binding; 2; . Pfam PF02197; RIIa; 1; . PIRSF PIRSF000548; PK_regulatory; 1; . SMART SM00100; cNMP; 2; . SMART SM00394; RIIa; 1; . SUPFAM SSF47391; SSF47391; 1; . SUPFAM SSF51206; SSF51206; 2; . PROSITE PS00888; CNMP_BINDING_1; 2; . PROSITE PS00889; CNMP_BINDING_2; 2; . PROSITE PS50042; CNMP_BINDING_3; 2; .

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